Nerve Health, Peripheral Neuropathy & Aging
Foundation for Peripheral Neuropathy. (2021, August 4). Vitamins and supplements for nerve health.
Hicks, C. W., Wang, D., Windham, B. G., Matsushita, K., & Selvin, E. (2021). Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts. Scientific Reports, 11, 19159.
National Institute of Neurological Disorders and Stroke. (n.d.). Peripheral neuropathy. National Institutes of Health.
Consumer Supplement Use & Healthy Aging Market
Stierman, B., Couch, C. A., Gahche, J. J., & Mishra, S. (2026). Dietary supplement use: United States, August 2021–August 2023. NCHS Data Brief, 561, 1–11. National Center for Health Statistics.
The Business Research Company. (2026). Healthy aging supplement global market report 2026.
Benfotiamine & Thiamine
Haupt, E., Ledermann, H., & Köpcke, W. (2005). Benfotiamine in the treatment of diabetic polyneuropathy—A three-week randomized, controlled pilot study (BEDIP study). International Journal of Clinical Pharmacology and Therapeutics, 43(2), 71–77.
National Institutes of Health, Office of Dietary Supplements. (n.d.). Thiamin: Fact sheet for health professionals.
Stracke, H., Gaus, W., Achenbach, U., Federlin, K., & Bretzel, R. G. (2008). Benfotiamine in diabetic polyneuropathy (BENDIP): Results of a randomised, double blind, placebo-controlled clinical study. Experimental and Clinical Endocrinology & Diabetes, 116(10), 600–605.
Ziegler, D., Sipola, G., Strom, A., Strassburger, K., Jander, L., Herder, C., Knebel, B., Reule, C., Jaghutriz, B. A., Yupanqui, A. C. M. T., Icks, A., Al-Hasani, H., Roden, M., Kuss, O., & Bönhof, G. J. (2026). Effects of benfotiamine treatment over 12 months on morphometric, neurophysiological and clinical measures in type 2 diabetes patients with symptomatic polyneuropathy: A randomized, placebo-controlled, double-blind clinical trial (BOND study). BMJ Open Diabetes Research & Care, 14(1), e005773.
Vitamin B12 & Neurological Function
National Institutes of Health, Office of Dietary Supplements. (n.d.). Vitamin B12: Fact sheet for health professionals.
Turmeric, Curcumin & Antioxidant Support
Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., Khamoshian, K., & Sotoudeh, G. (2019). Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo-controlled clinical trial. Complementary Therapies in Medicine, 43, 253–260.
Basu, P., Maier, C., & Basu, A. (2021). Effects of curcumin and its different formulations in preclinical and clinical studies of peripheral neuropathic and postoperative pain: A comprehensive review. International Journal of Molecular Sciences, 22(9), 4666.
National Center for Complementary and Integrative Health. (n.d.). Turmeric: Usefulness and safety. National Institutes of Health.
Regulatory & Claims Guidance
U.S. Food and Drug Administration. (n.d.). Label claims for conventional foods and dietary supplements.
U.S. Food and Drug Administration. (n.d.). Structure/function claims.
U.S. Food and Drug Administration. (n.d.). Small entity compliance guide on structure/function claims.